ABSTRACT
Background/Objectives: Genetic variants affecting host defense against pathogens may help explain COVID-19 fatal outcomes. Our aim was to identify rare genetic variants related to COVID-19 severity in a selected group of patients under 60 years who required intubation or resulting in death. Method(s): Forty-four very severe COVID-19 patients were selected from the Spanish STOP-Coronavirus cohort, which comprises more than 3,500 COVID-19 patients. Genotype was performed by whole exome sequencing and variants were selected by using a gene panel of 867 candidate genes (immune response, primary immunodeficiencies or coagulation, among other). Variants were filtered, priorized and their potential pathogenicity was assessed following ACGM criteria. Result(s): We detected 44 different variants of interest, in 29 different patients (66%). Some of these variants were previously described as pathogenic (26%). Mostly, the candidate variants were located in genes related to immune response (38%), congenital disorders of glycosylation (14%) or damaged DNA binding genes (9%). A network analysis, showed three main components, consisting of 25 highly interconnected genes related to immune response and two additional networks enriched in carbohydrate metabolism and in DNA metabolism and repair processes. Conclusion(s): The variants identified affect different, but interrelated, functional pathways such as immune response and glycosylation. Further studies are needed for confirming the ultimate role of the new candidate genes described in the present study on COVID-19 severity.
ABSTRACT
The main aim of this investigation was the implementation of Augmented Reality Technology (ART) in an activity of the education sector in elementary schools, with a deficient infrastructure of Information and Communication Technologies (ICT) in the northwest’s region of the Mexican Republic in the Mexicali and San Quintin cities. Also in this analysis evaluated the possibility of implementing the ART in industrial companies of Baja California State, Mexico and as a novel way to develop distance training processes, considering the current limitations of the Covid 19 pandemic. Another limitation of the training activity is the lack of economic resources on some occasions to attend events in other cities or places of training. This scientific study was very relevant because this analysis verified that the use of the ART in the activities and the aspects of ICT mentioned made it possible to work and generate productive and representative results. As the deficiency and lack of ICT is an occurrence in some regions of Mexico and is a concern of government and industries of the persons in charge of educational and industrial operations, this investigation would be an alternative method to make educational courses at distance or personality with students. This can also apply to industrial workers with training courses at distance or personality to improve the yielding operative workers. They used in some healthy activities to understand any thematic the ART in training courses as the understanding the Covi19 in some public or private clinics or hospitals and generates the adequate tools to combat it. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.